So I haven't read through all the thread tips yet (I'm working on it), so forgive if these already been mentioned.
1) For any of the self-employment careers where they sell stuff they've made (Sculptor, Nectar Making, Painter, etc), have them start as young as possible; then keep their stuff somewhere where it can appreciate in value.
My Nectar Maker capped out both his career and his LTW of Bottomless Nectar Cellar, only shortly after becoming a YA, because I just had all the nectar he'd been making tucked away in the nectar racks, and then I went and sold a good chunk of it.
2) A spare spouse or extra kid makes a great target for the Logic challenge to tutor skills. Also, tutoring boosts relationships, so you can get your friend requirement that way, too.
3) For male immortals, you can wait as long as you need before bringing in their spouse.
4) If you're going to travel, -do it early-! Otherwise it's just not really possible, because of how big the files are.
5) As a technical note, disabling memories helps with the massive file size; and (should) help keep games more stable and less glitchy.
6) Plan. Plan more. Have back-up plans. Then wing it and hope.
7) Know what skills interact. For example, it's hard (but not impossible) to raise Martial Arts without raising Athletics. So it's probably not a good idea to do both a Martial Arts and Athletics Supermax unless you want to keep a -very- close eye on your sims.
I found that having one immortal artist worked out really well. My Gen 4 took the LTW of Renaissance Sim, and then maxed Painting, Sculpting and Photography with a supermax (and career) in painting. It was really nice to not have to worry about skilling up yet another mortal to get the non-melting ice sculptures.
9) Mixology is a possible supermax . . . but the skill opportunities are very rare, and there's no associated career. I did Mixology and Stylist in my first Dynasty attempt, and that worked out ok (She also became the immortal painter for the Dynasty, and most of her opportunities came from the painting skill).
If you're going to go for mixology, remember that while teens can practice the skill, they can't order drinks (to learn other drinks) until they are YA.
They can, however, make drinks to get the challenge of making 500 drinks done, or at least started, before YA, provided you put a bar in at their home.
Also, the various drinks are actually wonderful boosts, the one I liked the most and always had glasses of laying around was the drink that boosts skill learning speed. You can start the skill at teen, but most of the other things you can't do until YA.
You will also have to micromanage them at some of the bars to get the skill challenges done. And, because a lot of the bars in Bridgeport have a celebrity star requirement, you'll have to make them somewhat of a celebrity, or be able to bribe your way into the bar.
