Hey, you're husband and wife: cool!
Well, I've used a cheat to bring him into CAS. Testingcheatsenabled true. And than shift plus click on my Sim to bring up the Edit in CAS function. The rest is history. 
I've tried it two, there times in a row. You mean I have to try it more?
Yep, we've been married just over 18 years now, and have been "living in Sim" since the original game, heh.
I just pulled my Flynn Sim into CAS using TestingCheatsEnabled On and set his Lifetime Wish to "CEO of a Maga-Corporation" (he's a "Paranormal Profiteer") and after exiting CAS his LTW stayed at what I set. That was at patch 1.32 with my mods enabled. I then removed the mods and tried it again. It also saved the change.
When we originally put them in Union Cove and ran into the problem at patch 1.31. Not sure what we did to fix it other than trying it a few times before it "stuck". Have you updated to 1.32 or 1.33 yet?
EDIT: I used TestingCheatsEnabled On at the main menu then loaded up my game and gave Flynn enough LTR points to choose Change Lifetime Wish. I then changed it to "CEO of a Mega-Corporation" and exited. The changed stuck. I then went to Edit in CAS and changed it back to "Paranormal Profiteer". And that stuck as well.
Flynn