Yes, It's a Get to Work thing. I immediately enlisted the help of the Landgraabs, (hate being poor), and once he was old enough I sent Malcolm into the Scientist career merely because I knew he would make several important items, a ray gun, (marvelous for making money by changing poor items into better higher priced ones!), a satellite, a cloning machine and the thing that gets you to Sixam. The two most important ones for me so far are the satellite dish, (not fond of aliens), and the cloning machine. So you have your founder buy ONE of each potion and reserve it for when you have the machine then clone away from that one. They store nicely.
No, you aren't allowed to clone death flowers, angelfish or potions of youth. Those you have to do the hard way.
Cloning takes very little time (I think it shows about 15 Sim minutes), but it can sometimes fail. You get this grey lump worth only $1 if it fails but it does not harm the original so only time lost. It meant that sometimes I had to follow Malcolm to work which left my founder doing other stuff, (like being at work herself), in order to get him to a high enough level to produce those items. Having science equipment in the house helped raise his eureka moments so he was promoted pretty quickly.
I do understand the grieving after all that work. I was moving quite along in TS3 with my dynasty there. The final straw was when the game ate all my museum pieces so no paintings of people. Couldn't recover from that and never finished it but it had been months of play. It was almost two years before I decided to attempt a dynasty and as I said, tons of failures before I even got a founder to the table.